Body Magnetic Resonance Research Group

Water–fat imaging and fat quantification

Research summary

Our technical work on water–fat imaging and fat quantification focuses on the following directions:

  • Development of SNR-efficient multi-echo gradient echo acquisition techniques for water–fat separation.
  • Robust fieldmap estimation in water–fat separation.
  • Removal of confounding effects in PDFF quantification using both imaging- and MRS-based techniques.
  • Development of MRS techniques to measure fat unsaturation.

Key publications

  • Ruschke, S., Eggers, H., Kooijman, H., Diefenbach, M.N., Baum, T., Haase, A., Rummeny, E.J., Hu, H.H., Karampinos, D.C., Correction of Phase Errors in Quantitative Water–Fat Imaging Using a Monopolar Time-Interleaved Multi-Echo Gradient Echo Sequence. Magnetic Resonance in Medicine 78, 984–996.

  • Ruschke, S., Kienberger, H., Baum, T., Kooijman, H., Settles, M., Haase, A., Rychlik, M., Rummeny, E.J., Karampinos, D.C., Diffusion-Weighted Stimulated Echo Acquisition Mode (DW-Steam) MR Spectroscopy To Measure Fat Unsaturation in Regions With Low Proton-Density Fat Fraction. Magnetic Resonance in Medicine 75, 32–41.

  • Karampinos, D.C., Ruschke, S., Dieckmeyer, M., Eggers, H., Kooijman, H., Rummeny, E.J., Bauer, J.S., Baum, T., Modeling of T 2 * Decay in Vertebral Bone Marrow Fat Quantification. NMR in Biomedicine 28, 1535–1542.

  • Karampinos, D.C., Melkus, G., Baum, T., Bauer, J.S., Rummeny, E.J., Krug, R., Bone Marrow Fat Quantification in the Presence of Trabecular Bone: Initial Comparison Between Water-Fat Imaging and Single-Voxel MRS. Magnetic Resonance in Medicine 71, 1158–1165.

  • Karampinos, D.C., Yu, H., Shimakawa, A., Link, T.M., Majumdar, S., Chemical Shift-Based Water/fat Separation in the Presence of Susceptibility-Induced Fat Resonance Shift. Magnetic Resonance in Medicine 68, 1495–1505.

  • Karampinos, D.C., Yu, H., Shimakawa, A., Link, T.M., Majumdar, S., T1-corrected Fat Quantification Using Chemical Shift-Based Water–fat Separation: Application To Skeletal Muscle. Magnetic Resonance in Medicine 66, 1312–1326.