Body Magnetic Resonance Research Group

Diffusion-weighted MRI and MRS

Research summary

Our technical work on diffusion-weighted MRI and MRS focuses on the following directions:

  • Development of diffusion acquisition techniques to overcome the limitations of single-shot EPI.
  • Development of diffusion signal modeling techniques.
  • Removal of the confounding effect of fat in diffusion measurements of the water component in tissues (e.g. skeletal muscle, bone marrow).
  • Development of high b-value DW-MRS to measure diffusion properties of fat and adipose tissue.

Key publications

  • Dieckmeyer, M., Ruschke, S., Eggers, H., Kooijman, H., Rummeny, E.J., Kirschke, J.S., Baum, T., Karampinos, D.C., ADC Quantification of the Vertebral Bone Marrow Water Component: Removing the Confounding Effect of Residual Fat. Magnetic Resonance in Medicine 78, 1432–1441.

  • Karampinos, D.C., Banerjee, S., King, K.F., Link, T.M., Majumdar, S., Considerations in High-Resolution Skeletal Muscle Diffusion Tensor Imaging Using Single-Shot Echo Planar Imaging With Stimulated-Echo Preparation and Sensitivity Encoding. NMR in Biomedicine 25, 766–778.

  • Hernando, D., Karampinos, D.C., King, K.F., Haldar, J.P., Majumdar, S., Georgiadis, J.G., Liang, Z.-P., Removal of Olefinic Fat Chemical Shift Artifact in Diffusion MRI. Magnetic Resonance in Medicine 65, 692–701.

  • Karampinos, D.C., King, K.F., Sutton, B.P., Georgiadis, J.G., Intravoxel Partially Coherent Motion Technique: Characterization of the Anisotropy of Skeletal Muscle Microvasculature. Journal of Magnetic Resonance Imaging 31, 942–953.

  • Valentinitsch, A., Karampinos, D.C., Alizai, H., Subburaj, K., Kumar, D., Link, T.M., Majumdar, S., Automated Unsupervised Multi-Parametric Classification of Adipose Tissue Depots in Skeletal Muscle. Journal of Magnetic Resonance Imaging 37, 917–927.

  • Karampinos, D.C., Van, A.T., Olivero, W.C., Georgiadis, J.G., Sutton, B.P., High-Resolution Diffusion Tensor Imaging of the Human Pons With a Reduced Field-Of-View, Multishot, Variable-Density, Spiral Acquisition At 3 T. Magnetic Resonance in Medicine 62, 1007–1016.